Keith Hornberger
@krhornberger
med chem @ Arvinas | PhD @ Columbia | hiker | cocktail enthusiast | he/him/huz/dad | dreaming of Sedona | while I have a connection to Arvinas, all opinions expressed are my own and do not represent the views, opinions, or positions of the company
Paul Workman was looking for more cocktail posts at AACR D3, so in honor of my recent vacation to Greece, here’s the Marvin’s Last Word: equal parts (3/4 oz) lime juice, gin, green Chartreuse, and mastiha (in place of the usual maraschino) + lime twist. Lovely.
Spotted today in Litochoro, Greece - near Mount Olympus @chemjobber.bsky.social
Pine Knob Loop in Sharon, CT. In just 2.5 mi and a fairly challenging 710’ vertical, you get awesome views of the Litchfield Hills, a short sojourn on the AT, a (dry-ish) waterfall, mountain laurel in full bloom, and… 90 minutes of solitude to recharge.
Bluebird day in the Litchfield Hills. Prospect Mountain Preserve, 3.8 mi and 660’ vertical. And two hours of blessed solitude.
Adios, San Diego - until we meet again. An awesome #AACR26 is in the books, and I’m on an airplane back to dreary northeastern spring
Next up at #AACR26 NDoH, Amphista disclosed their BRD9 degrader AMX-883
The final New Drugs on the Horizon session at #AACR26 is underway. It kicked off with Circle’s disclosure of their macrocyclic cyclin A/B inhibitor CID-078
Rounding out the second of three #AACR26 NDoH sessions, AstraZeneca disclosed a CD30 dual payload ADC
Next up at #AACR26 NDoH, Triana disclosed TRI-611, a molecular glue degrader of ALK
Next at #AACR26 NDoH, Novartis disclosed their CDK2 inhibitor ECI830
Second New Drugs on the Horizon is off and running at #AACR26. First up, Palleon disclosed their targeted sialidase E-688/HLX316.
Next up at #AACR26 NDoH, Tango Therapeutics disclosed TNG961, a molecular glue degrader of HBS1L
Next at #AACR26 NDoH, AstraZeneca disclosed AZD8359, a CD8-biased T cell engager.
A random smattering from the many excellent educational sessions at #AACR26 today - I’ll let you figure out the context for each
Fam… it’s been a week. Here’s the Zombie. 4 oz of rum in this bad boy (one of which is overproof), and per the directions is garnished with “a mint sprig and a healthy dose of trepidation”
For me it’s an Industry Sour, which is an equal parts witches brew of Fernet Branca, green Chartreuse, lime juice, and simple syrup, which somehow works.
My wife asked for “something with gin” tonight so I made the Army & Navy, which is basically a gin sour with orgeat instead of simple and a splash of Angostura bitters. Cheers friends!
Happy New Year 2026 from Aruba! Bon voyage, 2025 - not gonna miss you too much. 🏝️ 🎇
Spotted this on the card rack while out shopping today - who knew that the rest of the world is as into hydrogen bond donors as medicinal chemists are? ⚛️ 😉 #chemsky