Nucleic Acids Research
@narjournal
Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions
📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...
New research in #NARMolecularMedicine shows that #musclestemcells retain intrinsic #inflammatory changes, with aberrant #TNFα signaling and reduced #H3.3 impairing muscle regeneration, pointing to #newtherapeutic opportunities in #dermatomyositis beyond #interferon. 🧬 doi.org/10.1093/narm...
📣The 24th annual NAR Web Server Issue is now online! 📣Explore 47 new web servers spanning a range of scientific and medical applications. Congratulations and thanks to all authors, editors and reviewers for your contributions!🧬 #NARWebServer #MolecularBiology #OpenAccessIssue
📣 Applications are open for the next NAR Early Career Investigator (ECI) Advisory Board cohort! Work with Executive Editors, help shape journal strategy, and gain insight into peer review during a 2-year term. Apply by 1 Nov 2026: lnkd.in/g233ZCAf #ECR #NAR #AcademicPublishing #MolecularBiology
⭐ #NARBreakthrough ⭐ 🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/... @igmm-montpel.bsky.social
🎉Congratulations to the first authors Isidro Álvarez-Escribano and Manuel Brenes-Álvarez on their publication! Their study in the lab of Alicia M. Muro-Pastor presents a fascinating example of how RNA-based regulation fine-tunes #geneexpression 👏🔬 @ibvf-sevilla.bsky.social @unisevilla.us.es
⭐ #NARBreakthrough ⭐ 🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐ 🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social
📣 Applications are open for the next Editor‑in‑Chief of NAR Cancer! 📣 Lead an open‑access journal at the forefront of nucleic acids and cancer research. We welcome applications until 1st Aug 2026. More details: academic.oup.com/narcancer/pa... #NARCancer #EditorInChief #CancerResearch
⭐ #NARBreakthrough! ⭐ New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding. 📖 Read here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...
How do memories last a lifetime when proteins turn over in months? A new NAR review by Peter Cook suggests long‑term memory may stem from transcriptional gene clusters and even pyrophosphate shaping calcium signals. 📖 doi.org/10.1093/nar/... #LongTermMemory #Transcription #ReviewArticle
🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA
🎉 Congratulations to the first authors Rhyker Ranallo-Benavidez and Yue Hao on generating the first chromosome-level, phased genome assemblies for BJ and IMR-90 in the lab of Prof. Floris Barthel @tgenresearch.bsky.social @yuehao.bsky.social
⭐ #NARBreakthrough ⭐ New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource
🎉 Congratulations to first authors Carter Wheat and Zihao Qi on uncovering a new mechanism of ssDNA annealing. Their work in Prof. Charles E. Bell’s lab advances our understanding of RAD52 and its therapeutic potential in BRCA-mutant cancers. 🧬🔬 @ohiostatepress.bsky.social
⭐ #NARBreakthrough! ⭐ 🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers. 📖 Read here: doi.org/10.1093/nar/...
🔬 Modern #bioinformatics workflows are complex and hard to reproduce. #systemPipeR helps researchers design, run, and track analysis #pipelines in one framework, integrating R + bioinformatics tools, HPC support, and automated #reports for #transparency. Read more doi.org/10.1093/narg... #NARGAB
✨A new review in #NARMolecularMedicine explores how #mitochondrialDNA inheritance, copy number changes, and coordination with the nuclear genome shape development, and how #AssistedReproductiveTechnologies may disrupt this balance. Read the review here: doi.org/10.1093/narm... #EditorsChoice
⭐ #NARBreakthrough ⭐ 🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...
📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation
📣 NAR Cancer Call for Papers: Seeds of Cancer, Decades of Silence. Submit work on early cancer initiation, ageing, environment, clonal evolution, genome maintenance and more before July 2026. 👉 academic.oup.com/narcancer/pa... #NARCancer #CancerResearch #Genomics #Epigenetics
⭐NAR Breakthrough! ⭐ Back-to-back NAR studies show #Palbociclib binds #HIV TAR RNA with low affinity & striking specificity. Induced-fit RNA refolding creates a #druggable pocket, blocking #SEC recruitment.📖 Read the articles here: doi.org/10.1093/nar/... doi.org/10.1093/nar/... #DrugDiscovery
🎉 Congratulations to HaiyangDong and Yongfeng Jin on their new publication! An exciting step forward in understanding the complexity of RNA-mediated gene regulation! 👏 Well done to the entire team.
⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing
🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma! Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80
⭐NAR Breakthrough! ⭐ 🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social Read the full article here: doi.org/10.1093/nar/...
#SpinalMuscularAtrophy (SMA) is treated with the ASO Nusinersen (Spinraza™) to restore SMN via SMN2 splicing. 🧬 New work reveals diverse off-target effects linked to its chemistry—and shows how to mitigate them. 🚀 #NARMolecularMedicine #RNATherapeutics #ASO 🔗 Read here: doi.org/10.1093/narm...
⭐ #NARBreakthrough! ⭐ 🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency. @stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...